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The Guardian // Sport

From monkey elixir to fentanyl: Tyler Skaggs’s death is merely a chapter in baseball’s 136-year drug fix

Thursday 23rd October 2025, 9:00AM

As the LA Angels stand trial over the pitcher’s death in the quiet shadow of the World Series fanfare across town, a sport confronts a truth practically as old as the game itselfBefore steroids, before amphetamines and before fentanyl, baseball’s first documented chemical dalliance came from monkey testicles. In August 1889, a worn-down pitcher for the Pittsburgh Alleghenys named James Francis “Pud” Galvin, so nicknamed for his once-devastating ability to reduce hitters to “pudding”, was in need of a spark. He was 32, his right arm a rubbery relic of nearly 5,000 innings pitched, his career on the fade. Then came salvation in a syringe. A French-Mauritian doctor by the name of Charles-Édouard Brown-Séquard published a paper – The Effects Produced on Man by the Subcutaneous Injections of a Liquid Obtained from the Testicles of Animals – in which he claimed that a few drops of an extract sourced from dogs and guinea pigs might well make ordinary men stronger and more virile. Galvin, a stocky power pitcher, wasted no time getting jabbed with the so-called Brown-Séquard elixir in a public demonstration at the Western Pennsylvania Medical College, only four miles east from the team’s home ground. The next day he pitched a five-hit shutout to turn back the Boston Beaneaters, adding a double and a triple at the plate off the great Old Hoss Radbourn for good measure. (Take that, Ohtani.)“If there still be doubting Thomases who concede no virtue of the elixir, they are respectfully referred to Galvin’s record in yesterday’s Boston-Pittsburg game,” wrote the Washington Post, with proto-advertorial flourish. “It is the best proof yet furnished of the valu

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